contentSlug

type

ContentSlug_ContentQuery

slug

ContentPageContentQuery

content

trendingContent

query ContentSlug_ContentQuery(
  $contentSlug: String!
  $type: [ContentType!]
) {
  ...ContentPageContentQuery_13QmVO
}

fragment CompanyDetails_Content on Content {
  __isContent: __typename
  companies {
    name
    description
    pageUrl
    id
  }
}

fragment ContentBasicInfo on Content {
  __isContent: __typename
  id
  type
  title
  lang
  companies {
    viewerIsFollowing
    id
    name
    pageUrl
  }
  tags {
    viewerIsFollowing
    id
    name
    pageUrl
  }
  ...PublishingDetails
  ...Reactions
}

fragment ContentMetadata on Content {
  __isContent: __typename
  type
  title
  lang
  pageUrl
  alternatePageUrls: translations {
    __typename
    pageUrl
    lang
  }
  imgUrl
  description
  ... on Video {
    liveTime
    videoUrl
  }
  ... on Webcast {
    liveTime
    videoUrl
  }
}

fragment ContentPageContentQuery_13QmVO on Query {
  content(slug: $contentSlug, type: $type) {
    __typename
    id
    type
    title
    isPremium
    lang
    htmlBody
    summary
    companies {
      forum {
        latestPosts {
          ...ForumPosts
        }
      }
      name
      id
      viewerIsFollowing
      pageUrl
      defaultInstrument {
        isin
        id
        marketOpen
        marketClose
        marketplace {
          region
        }
        returns {
          total
        }
      }
    }
    tags {
      viewerIsFollowing
      id
      name
      pageUrl
    }
    createdAt
    ... on Video {
      liveTime
    }
    ... on Webcast {
      liveTime
    }
    slug
    ... on CompanyReport {
      reportUrl
    }
    ... on ThirdPartyCompanyReport {
      reportUrl
    }
    ... on StockExchangeRelease {
      reportUrl
    }
    ...ContentBasicInfo
    ...ContentMetadata
    ...PriceAndRecommendation_Content
    ...CompanyDetails_Content
    ...ReportLink_Content
    ...KeyFigures_Content
  }
  ...TrendingContent_1jQ2Cn
}

fragment ForumPosts on ForumPost {
  text
  likesCount
  url
  author
  postedAt
  authorImgUrl
}

fragment KeyFigures_Content on Content {
  __isContent: __typename
  companies {
    defaultInstrument {
      estimateData {
        modelType
        reportingCurrency
      }
      snapshot {
        transaction {
          date
          actualized {
            year
            quarter
            revenue
            revenueGrowth
            ebitAdjusted
            ebitReported
            ebitda
            enterpriseValue
            epsAdjusted
            dividend
            dividendYield
            sharePrice
          }
          estimates {
            year
            quarter
            revenue
            revenueGrowth
            ebitAdjusted
            ebitReported
            ebitda
            enterpriseValue
            epsAdjusted
            dividend
            dividendYield
            sharePrice
          }
        }
      }
      id
    }
    id
  }
}

fragment PriceAndRecommendation_Content on Content {
  __isContent: __typename
  createdAt
  companies {
    name
    pageUrl
    defaultInstrument {
      priceData {
        tradeCurrency
      }
      snapshot {
        priceData {
          date
          lastPrice
          tradeCurrency
        }
        transaction {
          date
          recommendation
          targetPrice
        }
        prevTransaction {
          recommendation
        }
      }
      id
    }
    id
  }
}

fragment PublishingDetails on Content {
  __isContent: __typename
  createdAt
  publishers {
    name
    imgUrl
  }
  authors {
    __typename
    id
    name
    slug
    imgUrl
    jobTitle
  }
  ... on Video {
    liveTime
  }
  ... on Webcast {
    liveTime
  }
}

fragment Reactions on Content {
  __isContent: __typename
  id
  reactionGroups {
    reactionType
    reactionsCount
    viewerReacted
  }
}

fragment ReportLink_Content on Content {
  __isContent: __typename
  type
  isPremium
  ... on CompanyReport {
    reportUrl
  }
  ... on ThirdPartyCompanyReport {
    reportUrl
  }
  ... on StockExchangeRelease {
    reportUrl
  }
}

fragment TrendingContent_1jQ2Cn on Query {
  trendingContent(type: ARTICLE) {
    __typename
    id
    title
    lang
    pageUrl
    createdAt
    type
    imgUrl
    companies {
      squareLogoUrl
      name
      id
    }
    authors {
      __typename
      imgUrl
      id
    }
    publishers {
      imgUrl
    }
  }
}


alz-101-immunization-generates-sustained-plasma-igg-and-predictable-csf-antibody-levels-against-neurotoxic-oligomers

__typename

title

isPremium

lang

htmlBody

summary

companies

createdAt

publishers

authors

reactionGroups

pageUrl

translations

imgUrl

description

Alzinova is a biotechnology company. The company specializes in the therapeutic treatment of Alzheimer's and conducts research and development of peptides that are further developed as vaccines. In addition, the company also develops various research tools within the field of work. The largest operations are found in the Nordic market. The company was founded in 2011 and has its headquarters in Mölndal.

Alzinova

Alzinova AB (Nasdaq First North: ALZ) announces new data showing that its vaccine candidate ALZ-101 generates sustained antibody levels in plasma and detectable levels in the cerebrospinal fluid...

<div class="mfn-preamble">Alzinova AB (Nasdaq First North: ALZ) announces new data showing that its vaccine candidate ALZ-101 generates sustained antibody levels in plasma and detectable levels in the cerebrospinal fluid. This supports the therapeutic potential of ALZ-101 by demonstrating exposure to the central nervous system, a key requirement for treating Alzheimer’s disease.</div><div class="mfn-body">Alzinova has previously reported that Alzheimer’s patients treated with six doses of its anti-oligomer vaccine, ALZ-101, for at least 12 months maintain high steady-state levels of plasma IgG antibodies targeting neurotoxic amyloid-beta (Aβ) oligomers, key pathogenic drivers of Alzheimer’s disease. Newly analyzed cerebrospinal fluid (CSF) data from a subset of patients now reveals detectable IgG antibodies also in the central nervous system (CNS), with CSF levels reaching at least 0.3% of those in blood. This CSF-to-plasma ratio aligns with benchmarks observed in passive monoclonal antibody therapies, reinforcing ALZ-101’s potential to achieve therapeutic antibody exposure in the brain. Further characterization of CSF antibody kinetics is ongoing.Tord Labuda, CEO of Alzinova AB, comments: ”We are very pleased to confirm that antibody titers are detectable in the central nervous system at levels comparable to other Alzheimer’s immunotherapies, and that sustained antibody exposure against relevant species—such as toxic Aβ oligomers in the brain—has been achieved. This not only demonstrates the therapeutic potential of ALZ-101 but also significantly strengthens the value of our underlying asset by providing evidence of central nervous system engagement.”For further information, please contact: Tord Labuda, CEO E-mail: info@alzinova.comAbout Alzinova AB Alzinova AB is a Swedish biopharmaceutical company in clinical development specializing in the treatment of Alzheimer's disease, where the starting point is to attack toxic amyloid-beta oligomers. The lead candidate ALZ-101 is a therapeutic vaccine against Alzheimer's disease. Alzinova's patented AβCC peptide technology makes it possible to develop disease-modifying treatments that target the toxic amyloid-beta oligomers that are central to the onset and development of the disease with great accuracy. From a global perspective, Alzheimer's disease is one of the most common and devastating neurological diseases, with around 40 million affected today. Based on the same technology, the company is also developing the antibody ALZ-201, which is currently in preclinical development, and the goal is to further expand the pipeline. The company's Certified Adviser on Nasdaq First North Growth Market is Mangold Fondkommission AB. For more information about Alzinova, please visit: <a rel="noopener" href="http://www.alzinova.com/">www.alzinova.com</a></div><div class="mfn-footer mfn-attachment mfn-attachment-general">Attachments <a rel="noopener" href="https://storage.mfn.se/75023eb9-ce36-488c-b31a-a846fe8dc645/alz-101-immunization-generates-sustained-plasma-igg-and-predictable-csf-antibody-levels-against-neurotoxic-oligomers.pdf" class="mfn-generated mfn-primary">ALZ-101 immunization generates sustained plasma IgG and predictable CSF antibody levels against neurotoxic oligomers</a></div>

ALZ-101 immunization generates sustained plasma IgG and predictable CSF antibody levels against neurotoxic oligomers