Circio Holding ASA (”Circio” or ”the Company”) announced, on the 24th of June 2026, a research collaboration with Tcelltech GmbH (”Tcelltech”), a Mannheim-based biotechnology company, to combine circVec with Tcelltech’s non-viral, non-integrating, episomal nanoSMAR DNA vector platform for next-generation engineered T-cell therapies, including in vivo CAR-T and TCR-T. The program runs in stages: an initial proof-of-concept phase comparing how strongly and how durable the technology combination drives gene expression in primary human T cells, followed by a functional phase in which CD19-directed CAR T cells are generated and assessed for their ability to kill tumor cells. No financial terms are disclosed.
In summary, Analyst Group views the Tcelltech collaboration as a technically coherent addition to Circio’s in vivo cell therapy portfolio. The non-viral, high-cargo nanoSMAR format addresses the delivery problem, while circVec addresses the expression-durability problem. These are complementary bottlenecks that together could form the basis of a differentiated in vivo CAR-T/TCR-T approach. That said, the program remains at an early preclinical stage with no disclosed financial terms. The cell therapy track also continues to represent a longer-dated optionality layer rather than a near-term value driver. On balance, Analyst Group assesses that the collaboration adds another credible partner to circVec’s delivery network and incrementally supports the platform’s licensing appeal.
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