contentSlug

type

ContentSlug_ContentQuery

slug

ContentPageContentQuery

content

trendingContent

query ContentSlug_ContentQuery(
  $contentSlug: String!
  $type: [ContentType!]
) {
  ...ContentPageContentQuery_13QmVO
}

fragment CompanyDetails_Content on Content {
  __isContent: __typename
  companies {
    name
    description
    pageUrl
    id
  }
}

fragment ContentBasicInfo on Content {
  __isContent: __typename
  id
  type
  title
  lang
  companies {
    viewerIsFollowing
    id
    name
    pageUrl
  }
  tags {
    viewerIsFollowing
    id
    name
    pageUrl
  }
  ...PublishingDetails
  ...Reactions
}

fragment ContentMetadata on Content {
  __isContent: __typename
  type
  title
  lang
  pageUrl
  alternatePageUrls: translations {
    __typename
    pageUrl
    lang
  }
  imgUrl
  description
  ... on Video {
    liveTime
    videoUrl
  }
  ... on Webcast {
    liveTime
    videoUrl
  }
}

fragment ContentPageContentQuery_13QmVO on Query {
  content(slug: $contentSlug, type: $type) {
    __typename
    id
    type
    title
    isPremium
    lang
    htmlBody
    summary
    companies {
      forum {
        latestPosts {
          ...ForumPosts
        }
      }
      name
      id
      viewerIsFollowing
      pageUrl
      defaultInstrument {
        isin
        id
        marketOpen
        marketClose
        marketplace {
          region
        }
        returns {
          total
        }
      }
    }
    tags {
      viewerIsFollowing
      id
      name
      pageUrl
    }
    createdAt
    ... on Video {
      liveTime
    }
    ... on Webcast {
      liveTime
    }
    slug
    ... on CompanyReport {
      reportUrl
    }
    ... on ThirdPartyCompanyReport {
      reportUrl
    }
    ... on StockExchangeRelease {
      reportUrl
    }
    ...ContentBasicInfo
    ...ContentMetadata
    ...PriceAndRecommendation_Content
    ...CompanyDetails_Content
    ...ReportLink_Content
    ...KeyFigures_Content
  }
  ...TrendingContent_1jQ2Cn
}

fragment ForumPosts on ForumPost {
  text
  likesCount
  url
  author
  postedAt
  authorImgUrl
}

fragment KeyFigures_Content on Content {
  __isContent: __typename
  companies {
    defaultInstrument {
      estimateData {
        modelType
        reportingCurrency
      }
      snapshot {
        transaction {
          date
          actualized {
            year
            quarter
            revenue
            revenueGrowth
            ebitAdjusted
            ebitReported
            ebitda
            enterpriseValue
            epsAdjusted
            dividend
            dividendYield
            sharePrice
          }
          estimates {
            year
            quarter
            revenue
            revenueGrowth
            ebitAdjusted
            ebitReported
            ebitda
            enterpriseValue
            epsAdjusted
            dividend
            dividendYield
            sharePrice
          }
        }
      }
      id
    }
    id
  }
}

fragment PriceAndRecommendation_Content on Content {
  __isContent: __typename
  createdAt
  companies {
    name
    pageUrl
    defaultInstrument {
      priceData {
        tradeCurrency
      }
      snapshot {
        priceData {
          date
          lastPrice
          tradeCurrency
        }
        transaction {
          date
          recommendation
          targetPrice
        }
        prevTransaction {
          recommendation
        }
      }
      id
    }
    id
  }
}

fragment PublishingDetails on Content {
  __isContent: __typename
  createdAt
  publishers {
    name
    imgUrl
  }
  authors {
    __typename
    id
    name
    slug
    imgUrl
    jobTitle
  }
  ... on Video {
    liveTime
  }
  ... on Webcast {
    liveTime
  }
}

fragment Reactions on Content {
  __isContent: __typename
  id
  reactionGroups {
    reactionType
    reactionsCount
    viewerReacted
  }
}

fragment ReportLink_Content on Content {
  __isContent: __typename
  type
  isPremium
  ... on CompanyReport {
    reportUrl
  }
  ... on ThirdPartyCompanyReport {
    reportUrl
  }
  ... on StockExchangeRelease {
    reportUrl
  }
}

fragment TrendingContent_1jQ2Cn on Query {
  trendingContent(type: ARTICLE) {
    __typename
    id
    title
    lang
    pageUrl
    createdAt
    type
    imgUrl
    companies {
      squareLogoUrl
      name
      id
    }
    authors {
      __typename
      imgUrl
      id
    }
    publishers {
      imgUrl
    }
  }
}


hamlet-hamlet-pharma-releases-further-data-from-clinical-study

__typename

title

isPremium

lang

htmlBody

summary

companies

createdAt

publishers

authors

reactionGroups

pageUrl

translations

imgUrl

description

At the end of July 2019, Hamlet Pharma announced the successful completion of the Phase I/II bladder cancer study. We now provide more detailed information about the study outcome. Twenty patients...

At the end of July 2019, Hamlet Pharma announced the successful completion of the Phase I/II bladder cancer study. We now provide more detailed information about the study outcome. Twenty patients were treated with Alpha1H and patients received 6 instillations during one month, followed by surgery to remove the tumor. A further visit was included to document the safety of Alpha1H. Another 20 patients received placebo. The main study outcomes are summarized below. A final study report is being prepared for publication in an international scientific journal.SAFETY ANALYSISThere were no side effects related to the Alpha1H treatment. We conclude that instillation of 1.7 mM of Alpha1H into the bladder can be regarded as safe.Adverse events (AEs)No. of AEs Active (n=20) Placebo (n=20) Total (n=40) Drug-related AEs 0 - 0 Serious AES 0 1 1 AE resulting in discontinuation 0 0 0EFFICACY VARIABLESI. Alpha1H triggers massive shedding of tumor cells into patient urineA rapid increase in cell shedding was detected in patients, who received Alpha1H compared to placebo (P&lt;0.0001). The cell shedding response was seen each time the patients received Alpha1H (Visit 1-6) but not in the placebo group. A similar increase was observed for tumor fragments, which were released into the urine of patients receiving Alpha1H (P&lt;0.0001).Picture added in pdf fileII. Alpha1H triggers cell death in the tumor (apoptosis)To examine how the tumor responds to Alpha1H, biopsies were obtained from the tumor at the time of surgery. Cell death in the tumor was defined by TUNEL staining, which detects apoptosis; a beneficial, non-toxic form of cell death. A highly significant increase was observed, compared to the placebo group. The results suggest that Alpha1H accelerates cell death in the tumor.Picture added in the pdf fileIII. Alpha1H is taken up by tumor cellsBy fluorescence microscopy, we show that Alpha1H is taken up by tumor cells, providing evidence that the drug candidate alpha1H interacts with the tumor.  Picture added in pdf fileThe results reveal clear differences between the Alpha1H and placebo groups, supporting the safety and therapeutic efficacy of Alpha1H.  "'The results boost our confidence in Alpha1H as a safe and efficient therapeutic and our efforts to accelerate drug development in bladder cancer and other cancer indications'' says Catharina Svanborg, founder, CMO and chairman of the board of Hamlet Pharma Ltd.   "The results are in line with the first data presented in July and allow us to take the next step in the development of Alpha1H" says Mats Persson, CEO of Hamlet Pharma Ltd.