contentSlug

type

ContentSlug_ContentQuery

slug

ContentPageContentQuery

content

trendingContent

query ContentSlug_ContentQuery(
  $contentSlug: String!
  $type: [ContentType!]
) {
  ...ContentPageContentQuery_13QmVO
}

fragment CompanyDetails_Content on Content {
  __isContent: __typename
  companies {
    name
    description
    pageUrl
    id
  }
}

fragment ContentBasicInfo on Content {
  __isContent: __typename
  id
  type
  title
  lang
  companies {
    viewerIsFollowing
    id
    name
    pageUrl
  }
  tags {
    viewerIsFollowing
    id
    name
    pageUrl
  }
  ...PublishingDetails
  ...Reactions
}

fragment ContentMetadata on Content {
  __isContent: __typename
  type
  title
  lang
  pageUrl
  alternatePageUrls: translations {
    __typename
    pageUrl
    lang
  }
  imgUrl
  description
  ... on Video {
    liveTime
    videoUrl
  }
  ... on Webcast {
    liveTime
    videoUrl
  }
}

fragment ContentPageContentQuery_13QmVO on Query {
  content(slug: $contentSlug, type: $type) {
    __typename
    id
    type
    title
    isPremium
    lang
    htmlBody
    summary
    companies {
      forum {
        latestPosts {
          ...ForumPosts
        }
      }
      name
      id
      viewerIsFollowing
      pageUrl
      defaultInstrument {
        isin
        id
        marketOpen
        marketClose
        marketplace {
          region
        }
        returns {
          total
        }
      }
    }
    tags {
      viewerIsFollowing
      id
      name
      pageUrl
    }
    createdAt
    ... on Video {
      liveTime
    }
    ... on Webcast {
      liveTime
    }
    slug
    ... on CompanyReport {
      reportUrl
    }
    ... on ThirdPartyCompanyReport {
      reportUrl
    }
    ... on StockExchangeRelease {
      reportUrl
    }
    ...ContentBasicInfo
    ...ContentMetadata
    ...PriceAndRecommendation_Content
    ...CompanyDetails_Content
    ...ReportLink_Content
    ...KeyFigures_Content
  }
  ...TrendingContent_1jQ2Cn
}

fragment ForumPosts on ForumPost {
  text
  likesCount
  url
  author
  postedAt
  authorImgUrl
}

fragment KeyFigures_Content on Content {
  __isContent: __typename
  companies {
    defaultInstrument {
      estimateData {
        modelType
        reportingCurrency
      }
      snapshot {
        transaction {
          date
          actualized {
            year
            quarter
            revenue
            revenueGrowth
            ebitAdjusted
            ebitReported
            ebitda
            enterpriseValue
            epsAdjusted
            dividend
            dividendYield
            sharePrice
          }
          estimates {
            year
            quarter
            revenue
            revenueGrowth
            ebitAdjusted
            ebitReported
            ebitda
            enterpriseValue
            epsAdjusted
            dividend
            dividendYield
            sharePrice
          }
        }
      }
      id
    }
    id
  }
}

fragment PriceAndRecommendation_Content on Content {
  __isContent: __typename
  createdAt
  companies {
    name
    pageUrl
    defaultInstrument {
      priceData {
        tradeCurrency
      }
      snapshot {
        priceData {
          date
          lastPrice
          tradeCurrency
        }
        transaction {
          date
          recommendation
          targetPrice
        }
        prevTransaction {
          recommendation
        }
      }
      id
    }
    id
  }
}

fragment PublishingDetails on Content {
  __isContent: __typename
  createdAt
  publishers {
    name
    imgUrl
  }
  authors {
    __typename
    id
    name
    slug
    imgUrl
    jobTitle
  }
  ... on Video {
    liveTime
  }
  ... on Webcast {
    liveTime
  }
}

fragment Reactions on Content {
  __isContent: __typename
  id
  reactionGroups {
    reactionType
    reactionsCount
    viewerReacted
  }
}

fragment ReportLink_Content on Content {
  __isContent: __typename
  type
  isPremium
  ... on CompanyReport {
    reportUrl
  }
  ... on ThirdPartyCompanyReport {
    reportUrl
  }
  ... on StockExchangeRelease {
    reportUrl
  }
}

fragment TrendingContent_1jQ2Cn on Query {
  trendingContent(type: ARTICLE) {
    __typename
    id
    title
    lang
    pageUrl
    createdAt
    type
    imgUrl
    companies {
      squareLogoUrl
      name
      id
    }
    authors {
      __typename
      imgUrl
      id
    }
    publishers {
      imgUrl
    }
  }
}


faron-pharmaceuticals-bexmab-studys-good-momentum-supports-valuation

__typename

title

isPremium

lang

htmlBody

summary

companies

createdAt

publishers

authors

reactionGroups

pageUrl

translations

imgUrl

description

Analyst

Antti Siltanen

Head of Nordic ER Development, Analyst

Antti Luiro

Faron is a global, clinical-stage biopharmaceutical company, focused on tackling cancers via novel immunotherapies. Its mission is to bring the promise of immunotherapy to a broader population by uncovering novel ways to control and harness the power of the immune system. The Company's lead asset is bexmarilimab, a novel anti-Clever-1 humanized antibody, with the potential to remove immunosuppression of cancers through reprogramming myeloid cell function. Bexmarilimab is being investigated in Phase I/II clinical trials as a potential therapy for patients with hematological cancers in combination with other standard treatments.

Ok  We did not get the background for these, nor the Kaplan-Meier. The dataset is likely very heterogeneous, and my concern about early censoring still persists.  So, as I said above, this is an investigator-assessed figure, meaning it’s biased, and central assessment does not reach the same figures, as it is 30% for the entire first-line, as Zeidan now told us.  Treatment response does not primarily determine whether a bone marrow transplant is performed. See HR-MDS treatment guidelines. Deep response likely refers to MRD figures, the definition method of which is unknown; this is the NGS vs. flow cytometry difference.  This seems to be at the level of aza (azacitidine), if healthier patients are treated. See Bexmab inclusion and exclusion criteria. In all results, the small size of the dataset and the resulting confidence intervals should be noted.

Ok​:+1: you want to help investors and now you found this link

https://ashpublications.org/blood/article/doi/10.1182/blood.2025029727/548015/The-conundrum-of-drug-development-in-higher-risk I won’t bother, I’ll just quote smarter people. Here’s a recent publication by our esteemed Professor Zeidan. It costs a hundred. At the end, a tabulation of recent MDS trials and their responses.

So all 700 biotechs report more clearly? And Zeidan reported results that are the same as with just aza… oh come on.

Lest there be a misunderstanding, this interpretation is false concerning the TP53 mutation. Furthermore, your interpretation only applies to HR MDS wt patients. In addition, your interpretation focuses on CR.

I heard it exactly as stated. This has certainly not been made easy for investors, as the texts are full of composite CR and CR figures, IWG2006 and IWG2023 criteria, and TP53 subgroups all mixed up. Here’s how it goes for the first line: IWG2006:  CR 45%  WtTP53 CR: 20%  mTP53 CR: 70% IWG2023: composite CR 55% (in Zeidan’s video above, according to the abstract this figure was for wtTP53 and mTP53 would have been 44%)  CR 30% (this was new information at least) The difference must come from IWG2006 being investigator assessed and IWG2023 being central assessment. Meaning different people evaluate the result. I believe the background of the difference is the short-term CRs of transplant recipients, which do not pass independent review. Let’s also remember that in the IWG2023 criteria, the Hb threshold has been lowered for CR, so it is easier to achieve than with the 2006 criteria; the percentages are thus precisely the other way around. I assume here that the 30% CR mentioned by Zeidan also includes CRequivalent. I don’t know if anyone can still follow this. Let’s just say in plain language that the responses with bex+aza are at the same level as with aza alone when treating research patients.

I understand. From some Faron material, I had already inferred that NGS would have been used. I interpret that old samples have been dug up for more detailed analysis and then TP53m was found.

Faron Pharmaceuticals

Faron again published positive results of the BEXMAB study that focuses on blood cancers. The company seems to have preliminary efficacy proof already in the phase I/II study, which we believe...

<p>Faron again published positive results of the BEXMAB study that focuses on blood cancers. The company seems to have preliminary efficacy proof already in the phase I/II study, which we believe supports the probabilities of the study path being successful. With the positive estimate changes justified by the results we feel that the valuation picture of the share is slightly more neutral, but still not sufficiently attractive in terms of the risk/return ratio. </p> 

	2022	23e	24e
Revenue	0.0	0.0	0.0
growth-%
EBIT (adj.)	-27.4	-15.8	-3.1
EBIT-% (adj.)	-685,650.0 %	-394,522.5 %	-76,864.0 %
EPS (adj.)	-0.48	-0.25	-0.05
Dividend	0.00	0.00	0.00
Dividend %
P/E (adj.)	neg.	neg.	neg.
EV/EBITDA	neg.	neg.	neg.

Faron Pharmaceuticals: BEXMAB study’s good momentum supports valuation

Key Estimate Figures2023-04-17

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