Circio Holding ASA ("Circio" or "the Company") announced, on the 16th of July 2026, a research collaboration with Avenue Biosciences, a transatlantic protein engineering company, to combine their technologies to improve long-term expression of secreted proteins for the treatment of genetic and chronic diseases. Avenue Biosciences will deploy its machine learning-powered platform, which screens thousands of signal peptide variants, to identify sequences that improve secretion of therapeutic proteins expressed by circVec, with initial screening performed by Avenue Biosciences followed by in vitro and in vivo testing by Circio. No financial terms are disclosed.
In summary, Analyst Group views the Avenue Biosciences collaboration as an important extension of Circio's 2026 partnership activity that adds a payload-focused complement to the Company's delivery-side collaborations. Given the early stage of the collaboration and the absence of disclosed terms, Analyst Group assesses the near-term financial materiality as limited, while noting the collaboration as a further data point supporting circVec's positioning as a broadly applicable expression platform.
Read Analyst Group’s comment here
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