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Analytikerkommentar

ExpreS2ion Biotechnologies: Expanding ES2B-C001 study to include combination testing

Av Michael FriisHead of Equities
ExpreS2ion Biotech Holding

ExpreS2ion has today announced that it has submitted a study protocol amendment to the Austrian regulatory authorities for its Phase 1 ES2B-C001 breast cancer study. The amendment aims to enable evaluation of its breast cancer vaccine candidate, ES2B-C001, in combination with antibody-drug conjugates (ADCs), and to expand the number of study sites.

In addition to increasing the number of clinical trial sites in Austria—making it more likely that the study can be completed within the expected timeline—the inclusion of ES2B-C001 in combination treatments is also expected to accelerate patient recruitment. This is because combination therapy better aligns with current treatment standards, thereby increasing the number of eligible patients.

The company also states that these changes to the protocol are not expected to affect the overall timeline, as the original trial continues under the current protocol. An update on timelines will be provided when the first patient has been dosed.

Beyond supporting the study’s timely execution, testing ES2B-C001 in combination with other treatments could also generate additional data that may strengthen the commercial potential of the vaccine, as it has future potential to be used as an add-on to currently recommended treatments.

ExpreS2ion Biotechnologies is expected to release its Q1 2025 results on 15 May 2025. At 10:30 CET on the same day, we are hosting an event with management. In addition to the quarterly results, the discussion could focus on today’s announcement and the potential of expanding the study, as well as the prospects of the recently announced partnership with WuXi Biologics regarding the ExpreS2™ technology platform.

Sign up for the event here: https://www.inderes.dk/videos/expres2ion-biotechnologies-presentation-of-q1-2025

Disclaimer: HC Andersen Capital receives payment from ExpreS2ion Biotechnologies for a Digital IR/Corporate Visibility subscription agreement.— Michael Friis, 13:03, 13-05-2025

 

ExpreS2ion är ett bioteknikbolag fokuserat på utveckling av vacciner. Bolagets mål att bidra till hälso- och sjukvården genom att utveckla vacciner ämnade att stödja sjukdomsförebyggande och förbättra livskvaliteten globalt. ExpreS2ion använder sin ExpreS2™-teknologiplattform, som har validerats i kliniska fas III-studier, för utveckling och produktion av vaccinkomponenter. Bland pågående projekt utvecklar bolaget ES2B-C001, ett HER2-cVLP bröstcancervaccin som genomgår kliniska fas I-prövningar.

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